Crystal structure of BACE1 in complex with (Z)-fluoro-olefin containing compound 15
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Crystal structure of BACE1 in complex with (Z)-fluoro-olefin containing compound 15 Descriptor: 6-[(Z)-2-{3-[(1S,5S,6S)-3-amino-5-methyl-1-(morpholine-4-carbonyl)-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4-fluorophenyl}-1-fluoroethenyl]pyridine-3-carbonitrile, Beta-secretase 1, IODIDE ION Authors: Whittington, D.A. Deposit date: 2020-04-23 Release date: 2020-06-03 Last modified: 2024-11-20 Method: X-RAY DIFFRACTION (1.86 Å) Cite: The development of a structurally distinct series of BACE1 inhibitors via the (Z)-fluoro-olefin amide bioisosteric replacement. Bioorg.Med.Chem.Lett., 30, 2020
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2020-04-23
