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A phase lb/ll, open label, single arm study to assess efficacy and safety of alpelisib and capecitabine in patients with PIK3CA mutant metastatic colorectal cancer who failed two prior standard chemotherapies
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下载链接：
https://www.omicsdi.org/dataset/ecrin-mdr-crc/2513615
下载链接
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资源简介：
Interventions: Drug : Alpelisib: oral administration
In Phase lb, 200mg and 300mg once daily will be tested.
In Phase ll, the recommended phase ll dose (RP2D) in phase lb will be used.
Capecitabine: oral administration,
In Phase lb, 850mg, 1000mg, 1250mg twice daily will be tested.
In Phase ll, the recommended phase ll dose (RP2D) in phase lb twice daily on day 1 to 14 followed by 7 days off
Primary outcome(s): PFS, Progression Free Survival
创建时间：
2021-01-15
