Crystal Structure of Human HDAC8 Inhibitor Complex, an Amino Acid Derived Inhibitor
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Crystal Structure of Human HDAC8 Inhibitor Complex, an Amino Acid Derived Inhibitor Descriptor: (2R)-2-amino-3-(3-chlorophenyl)-1-[4-(2,5-difluorobenzoyl)piperazin-1-yl]propan-1-one, Histone deacetylase 8, POTASSIUM ION, ... Authors: Stams, T, Vash, B. Deposit date: 2011-06-13 Release date: 2011-07-20 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2 Å) Cite: Human HDAC isoform selectivity achieved via exploitation of the acetate release channel with structurally unique small molecule inhibitors. Bioorg.Med.Chem., 19, 2011
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2011-06-13
