Average game centrality (GC) values for E. coli methionyl-tRNA synthetase amino acids.

aProtein structure network of E coli methionyl-tRNA-synthetase was constructed, Prisoner’s dilemma game was simulated, and game centrality measures were calculated as described in Methods.bDomains from top to bottom: the catalytic domain including the Rossmann-fold-1 (catalytic function), Rossmann-fold-2 and stem contact fold (KMSKS) sub-domains; the connecting peptide (CP) domain; the anticodon binding, carboxy-terminal domain, 43 signaling amino acids involved in the transmission of conformational change as shown by Ghosh and Vishveshwara [46], whole methionyl-tRNA synthetase.