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Enzymes, efflux pumps, and mutations expected to confer resistance to antibiotics of clinical relevancea.

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aExcluding the resistance enzyme for bleomycin, an antibiotic used clinically only as an antitumor agent.bVariant number from Table 1 of Ramirez et al.[37] is used to distinguish the AAC(6′)-Ib variants.cTwo silent differences between the two copies.dProbable efflux substrates identified from literature sources including ARDB; the substrates list is not comprehensive and in many cases has been deduced from organisms other than K. pneumoniae.eMdt genes are scattered over the chromosome.

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2015-12-02
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