Htt

Enables diazepam binding activity. Involved in several processes, including postsynapse to nucleus signaling pathway; regulation of cAMP-dependent protein kinase activity; and regulation of protein localization to nucleus. Acts upstream of or within several processes, including carboxylic acid metabolic process; positive regulation of cilium assembly; and transport along microtubule. Located in several cellular components, including centriole; inclusion body; and perinuclear region of cytoplasm. Is active in glutamatergic synapse. Is expressed in several structures, including central nervous system; olfactory epithelium; peripheral nervous system; retina; and testis. Used to study Huntington's disease. Human ortholog(s) of this gene implicated in Huntington's disease and Parkinson's disease. Orthologous to human HTT (huntingtin). [provided by Alliance of Genome Resources, Nov 2024]

该数据集具备地西泮结合活性。参与多项生理过程，包括突触后至细胞核的信号传导通路；调节cAMP依赖性蛋白激酶活性；以及蛋白质在细胞核中的定位调控。在包括羧酸代谢过程；纤毛组装的正调控；以及微管运输等多个过程中发挥上游作用或位于其中。位于多个细胞组分中，包括中心体；包涵体；以及细胞质核周区域。在谷氨酸能突触中表现出活性。在包括中枢神经系统；嗅觉上皮；外周神经系统；视网膜；和睾丸等多个结构中表达。用于研究亨廷顿病。与亨廷顿病和帕金森病相关的基因人类同源物。与人类HTT（亨廷顿蛋白）同源。[由基因组资源联盟提供，2024年11月]