The results of gene-environment interaction analysis for top-10 SNPs (P<0.05).

ars9469089 (RNF5), rs1049970 (CDH5), rs10201627 (GPR55) and rs4855881 (APEH);bMean and stand deviation of the rate of FEV1 decline (ml/month);cCoefficient, stand error, P value were acquired from linear regression model adjusted for height, age and FEV1 at baseline, and average log transformed endotoxin level.dP value for gene-environment interaction.eFDR q-value calculated based on top-10 SNPs (10 pairs for Age-SNP interactions and 10 pairs for SNP-Endotoxin interactions).