Observed Frequencies of Critical Residues for DNA Binding Found as Central Residues in Simulated Conformers of TBP.

The observed frequencies of DNA-binding null mutant positions (WT residue) for each of the 4 molecular simulations, including: a) TBP+WtDNA, b) TBP-WtDNA, c) TBP and d) TBP-GCDNA. The frequencies were obtained by normalizing the number of times any of the residues in this table was detected as central in all of the 63,000 conformations analyzed.