RNA-seq analysis of peripheral nerve with conditional knockout of Bap1 deubiquitinase.

The goal of the experiment was to determine the role of H2A deubiquitinase in the nerve injury response in peripheral nerve. A Schwann cell specific knockout of the H2A deubiquitinase (Bap1) was generated to compare with wild type mice. For each condition, three independent biological replicates were prepared.本实验旨在明确H2A去泛素化酶（H2A deubiquitinase）在外周神经损伤应答中的作用。研究人员构建了施万细胞特异性敲除该酶（Bap1）的小鼠模型，并与野生型小鼠开展对照实验。每种实验条件均设置3次独立生物学重复。