Time point RNA-seq of Dux over expression samples reveals different transcriptomes of Dux induction in mESC

Prevous study has discoverd 2CLC trancriptome and MERVL can be up-regulated by Dux over expression,but rarely has been found about the whole procedure of Dux-induced 2C-entry and exit process and whether this system can reflect the natural 2-cell embryo development,so we we defined different time point transcription after Dux over expression,and try to establish a link between gene expression profile between gene dynamics in different Dux over expression time point and in early mouse embryo development We then performed gene expression clustering analysis using data obtained from RNA-seq of 0h,12h,24h,36h,48h,72h samples after Dux over expression