Staphylococcus aureus F98Y DHFR complexed with iclaprim

Staphylococcus aureus F98Y DHFR complexed with iclaprim Descriptor: 5-{[(2S)-2-cyclopropyl-7,8-dimethoxy-2H-chromen-5-yl]methyl}pyrimidine-2,4-diamine, Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Authors: Oefner, C, Dale-Glenn, E. Deposit date: 2009-01-08 Release date: 2010-01-12 Last modified: 2024-05-29 Method: X-RAY DIFFRACTION (2.35 Å) Cite: Increased hydrophobic interactions of iclaprim with Staphylococcus aureus dihydrofolate reductase are responsible for the increase in affinity and antibacterial activity J.Antimicrob.Chemother., 63, 2009