Intersection of the host Hippo pathway components and the Ebola virus lifecycle

We observed a significant inhibition of Ebola virus (EBOV) infection in the YAP/TAZ double knockout HEK293 cells compared to the wild-type cells. As YAP and TAZ serve as the downstream effectors of the host Hippo signaling pathway and are the key transcriptional co-activators in the nuclear, we then performed gene expression profiling analysis to investigate which genes may play a mechanistic role in regulating EBOV infectivity and egress.