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Phage-display profiling of CDR3a loops of a NY-ESO-1 specific TCR

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NIAID Data Ecosystem2026-05-10 收录
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https://www.ncbi.nlm.nih.gov/sra/ERP177789
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TCRs bind to their target with high specificity. To explore this specificity, we used phage display to diversify the CDR3a of a TCR known to bind to the cancer testis antigen NY-ESO-1 (A0201_SLLMWITQC). The phage TCR library with diversified CDR3a was selected against this epitope. The pre- and post-selection phage libraries were sequenced with Illumina-based sequencing machines.
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2026-01-20
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