Ni/Pd Dual-Catalysis Strategy for C(sp2)–Sb Cross-Coupling of Halostibines with Aryl Triflates and Applications of Products as Coupling Reagents, Ligands, and Anticancer Compounds

A novel and efficient dual-catalysis strategy using nickel and palladium has been developed for the cross-coupling of halostibines with aryl triflates to form C(sp2)–Sb bonds. This approach shows a wide substrate scope and high functional group tolerance and could be conducted on a gram scale. The synthesized arylstibines also could be arylation reagents reacting with alkyl and phenyl alkenes to form olefins and ligands to regulate the hydrogenation of diphenylacetylene. In addition, synthesized arylstibine 3q also shows satisfactory anticancer activity against cancerous MDA-MB-231 cells.