Epigenetic profiles of HSCs transduced with control or Runx3-expressing lentivirus
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE219004
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To determine if ectopic expression of Runx3 can correct deficient lymphoid output in aged HSCs, we examine the chromatin profile of aged HSC transduced with control or Runx3-expressing lentivirus. Control or Runx3-expressing lentivirus was used to infect cKit-enriched bone marrow cells from aged (24 months) mice. Transduced cells were transplanted into lethally irradiated mice. After 16 weeks of transplantation, transduced donor-derived HSCs (LSK Flt3-CD150+CD48-CD45.2+hCD2+) were FACS sorted for ATAC-seq profiling.
创建时间：
2023-02-22
