The oral and fecal microbiome in chronic pancreatitis and pancreatic cancer.. The oral and fecal microbiome in chronic pancreatitis and pancreatic cancer.

Pancreatic ductal adenocarcinoma (PDAC), the most frequent form of pancreatic cancer, poses an increasing disease burden worldwide. Recent evidence suggests a role for the microbiome in PDAC etiology and progression. We analysed the fecal and salivary microbiota in a prospectively recruited population of treatment-naïve PDAC patients, chronic pancreatitis patients and healthy controls using shotgun metagenomic and 16S rRNA amplicon sequencing.