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A novel bat coronavirus closely related to SARS-CoV-2

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NIAID Data Ecosystem2026-03-11 收录
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https://www.ncbi.nlm.nih.gov/sra/SRP277112
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Although bats are regarded as the most likely natural hosts for SARS-CoV-2, the origins of the virus remain unclear. We reported a novel bat-derived coronavirus, denoted RmYN02, identified from a metagenomics analysis of bat samples, which shared 93.3% nucleotide identity with SARS-CoV-2 at the scale of the complete virus genome and 97.2% identity in the 1ab gene and characterized by the insertion of multiple amino acids at the junction site of the S1 and S2 subunits of the spike (S) protein. This provides strong evidence that such insertion events can occur naturally in animal betacoronaviruses.
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2020-08-12
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