Effects of different diets on autophagy control and unfolded protein response in the aging heart

We reported a decrease in mitochondrial function in the hearts of aging mice undergone a low protein diet, but an increased lifespan. For that, we hypothesized that the increased autophagy and unfolded protein response plays an important role in this phenomenon. For that, we want to identify changes in the heart transcriptome profiling (RNA-seq) that could explain this lifespan increased in aging mice. Overall design: Heart samples from aging mice were undergone to normal protein, low protein, high- fat diet and high-fat diet plus low protein.