PREPRATON AND CHARACTERIZATION OF STEROID-LINKED DERIVATIVES AS ANTICANCER AGENTS"

of a variety of regulatory function such as ovulation, development of corpusluteum, and maintenance ofuterine quiescence during pregnancy. It is also involved in proliferation and differentiation of mammaryglands. The biological activity of progesterone is mediated by the progesterone receptor [PR], a memberof the large gene family of nuclear receptors, which induces a cascade of transcriptional events afterbinding with the hormone. PR contains three functional domains including the N-terminus, a centrallylocated DNA binding domain (DBD) and C-terminal ligand binging domain (LBD) respectively. Thebinding of progesterone induces of conformational change in PR that promotes dissociation from amulti-protein complex followed by homo dimerization and binding to specific progesterone responseelements (PRE) within the promoter genes. The hormone activated PR recruits co-activators throug