The ratio of viable cells after 72-h treatment with mitoxantone at a range of concentrations in the presence of LY294002 or rapamycin by CKK8 assay.

Each value represents the mean value ± s.d. from three individual experiments. * Versus cells without LY294002 or rapamycin treatment within each cell group, P<0.05. †Versus K562 wild-type cells without LY294002 or rapamycin when treated with the same concentration of mitoxantrone, P<0.05. ‡Versus K562/AO2 cells among all of the experimental cells treated with LY294002, P<0.05. §Versus K562/AO2 cells among all the experimented cells treated with rapamycin, P<0.05.