Supporting data for "High-quality Schistosoma haematobium genome achieved by single-molecule and long-range sequencing"

<i>Schistosoma haematobium</i> causes urogenital schistosomiasis, a neglected tropical disease affecting &gt; 100 million people worldwide. Chronic infection with this parasitic trematode can lead to urogenital pathology including female genital schistosomiasis (FGS) and bladder cancer. At the molecular level, little is known about the biology of this blood fluke and the pathogenesis of the disease that it causes. To support molecular studies of this carcinogenic worm, we reported a draft genome for <i>S. haematobium</i> in 2012. Although a useful resource, the utility of this draft genome has been somewhat limited by its fragmentation. <br>Here, we systematically enhanced the draft genome of <i>S. haematobium</i> using a single-molecule and long-range DNA sequencing approach. We achieved a major improvement in the accuracy and contiguity of the genome assembly, making it superior or comparable to assemblies for other schistosome species. We transferred curated gene models to this assembly and, using enhanced gene annotation pipelines, inferred a gene set with as many or more complete gene models compared with those of other well-studied schistosomes. Employing conserved, singlecopy orthologs, we assessed the phylogenetic position of <i>S. haematobium</i> in relation to other parasitic flatworms for which draft genomes were available. <br>We report a substantially enhanced genomic resource that represents a solid foundation for molecular research on <i> S. haematobium</i> and is poised to better underpin population and functional genomic investigations, and to accelerate the search for new disease interventions.