Action-at-a-distance mutations analyzed by the advanced supF mutagenesis assay. Shuttle vector pSP189

Oxidative damage-induced mutations, apart from the damaged sites, known as action-at-a-distance mutations, exist as one of the mutation-inducing mechanisms in human cells. However, many aspects of the underlying molecular mechanisms remain unclear. To elucidate the mechanism, a comprehensive analysis was conducted using the advanced supF mutagenesis assay.