Table_1_Genetic Risk, Vascular Function, and Subjective Cognitive Complaints Predict Objective Cognitive Function in Healthy Older Adults: Results From the Brain in Motion Study.docx

Aging is associated with subjective memory complaints. Approximately half of those with subjective memory complaints have objective cognitive impairment. Previous studies have provided evidence of an association between genetic risk for Alzheimer’s disease (AD) and dementia progression. Also, aging is a significant risk factor for vascular pathology that may underlie at least some of the cognitive changes. This study investigates the relative contribution of subjective cognitive complaints (SCC), vascular function, and genetic risk for dementia in predicting objective cognitive performance. Multiple regression and relative importance analysis were used to investigate the relative contribution of vascular function, self-reported SCC, and dementia genetic risk, in predicting objective cognition in a sample of 238 healthy community-dwelling older adults. Age, sex, premorbid cognitive abilities, subjective verbal memory complaints, higher cerebrovascular blood flow during submaximal exercise, and certain dementia risk alleles were significant predictors of worse objective verbal memory performance (p < 0.001, R2 = 35.2–36.4%). Using relative importance analysis, subjective verbal memory complaints, and certain dementia risk alleles contributed more variance than cerebrovascular measures. These results suggest that age-related changes in memory in healthy older adults can be predicted by subjective memory complaints, genetic risk, and to a lesser extent, cerebrovascular function.

衰老与主观记忆投诉相关联。约有一半的主观记忆投诉者存在客观认知障碍。先前的研究已提供证据，表明阿尔茨海默病（AD）的遗传风险与痴呆进展之间存在关联。此外，衰老是血管病理学的重要风险因素，这种病理学可能至少是某些认知变化的潜在原因。本研究旨在探究主观认知投诉（SCC）、血管功能以及痴呆遗传风险在预测客观认知表现中的相对贡献。通过多元回归和相对重要性分析，研究了血管功能、自报的SCC和痴呆遗传风险在预测238名健康社区居住的老年人客观认知中的相对贡献。年龄、性别、前驱认知能力、主观言语记忆投诉、亚最大运动时的较高脑血流以及某些痴呆风险等位基因是预测较差的客观言语记忆表现的显著预测因素（p < 0.001，R² = 35.2–36.4%）。通过相对重要性分析，主观言语记忆投诉和某些痴呆风险等位基因相较于脑血流测量贡献了更多的变异。这些结果表明，健康老年人的年龄相关记忆变化可以通过主观记忆投诉、遗传风险以及在一定程度上通过脑血流功能进行预测。