Processed single-cell RNA-seq count matrices of PBMCs from patients with myasthenia gravis and healthy controls

Processed single-cell RNA-seq count matrices of peripheral blood mononuclear cells from patients with myasthenia gravis and healthy controls What this record contains Processed 10x Genomics 3' single-cell RNA-seq count matrices for seven peripheral blood mononuclear cell (PBMC) samples: three healthy controls (H1, H2, H3) and four patients with myasthenia gravis (M0707_01, M0709_02, M0709_03, M210715_01). File Sample Group H1_matrix.tar.gz H1 healthy control H2_matrix.tar.gz H2 healthy control H3_matrix.tar.gz H3 healthy control M0707_01_matrix.tar.gz M0707_01 myasthenia gravis M0709_02_matrix.tar.gz M0709_02 myasthenia gravis M0709_03_matrix.tar.gz M0709_03 myasthenia gravis M210715_01_matrix.tar.gz M210715_01 myasthenia gravis Each archive is a standard 10x Genomics filtered count matrix and contains exactly three files: matrix.mtx.gz barcodes.tsv.gz features.tsv.gz sample_metadata.tsv lists the sample-level metadata (donor, group, tissue, library strategy, instrument model) in the format used for the GEO submission of the same data. Processing Reads were processed with Cell Ranger (10x Genomics) to filtered count matrices. Downstream analysis applied donor-aware adaptive quality control (per-sample minimum detected genes 200-479; maximum mitochondrial fraction 11.9-16.5%), doublet removal with scDblFinder (6.5-12.5% of cells removed per sample; 111,898 singlets retained in total), marker-based annotation of the reviewed immune cell populations, and Harmony correction (used for