Asymmetric Conjugate Addition to α‑Substituted Enones/Enolate Trapping
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https://figshare.com/articles/dataset/Asymmetric_Conjugate_Addition_to_Substituted_Enones_Enolate_Trapping/2336497
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资源简介：
An
NHC–Cu complex catalyzed the asymmetric conjugate addition
(ACA) of various Grignard reagents to nonactivated α-substituted
cyclic enones to give 2,3-dialkylated cyclopentanones and cyclohexanones.
The Michael addition features the formation of a magnesium enolate
intermediate. One-pot diastereoselective trapping of this enolate
by alkyl, propargyl, allyl, and benzyl halides led to ketones with
contiguous α-quaternary and β-tertiary centers.
创建时间：
2016-02-18
