Patient characteristics of the hepato-gastrointestinal cohort.

P values were calculated with a paired two-sided t-test (*) or the Wilcoxon test (†). Immunohistochemistry data depict the overall expression of LGR5 in malignant (TU) and corresponding non-malignant (NT) tissue. Immunoreactivity scores (IRS) were calculated for tumour cells. n.d. = not detected. AC = adenocarcinoma. SCC = squamous cell carcinoma. HCC = hepatocellular carcinoma. CC = cholangiocarcinoma. m = man. w = woman. LGR5+ = number (n) and percentage (%) of LGR5+ cases.