Metatranscriptomics of small intestine revealed Anaerostipes hadrus a key microbial feature on dietary fibre promoting metabolomic health in elderly

Analysis of colonoscopic bile aspirate samples revealed the impact of excess of free fatty acids on microbiome changes in a small intestine which affected microbiota composition down in the colon. Fatty acids which were not absorbed efficiently in ileum of NAFLD patients remained longer in the gut and might increase activity of microbes able to metabolise the long chain fatty acids together with expression of other functions like bile acid transformation, BCAA metabolism and indoles. While DGLA was only PUFA-n6 significantly associated with obesity, active A. hadrus culture from lean patients might decrease DGLA concentration in the gut. Administration of specific fiber with DGLA metabolite from A. hadrus might be used as a strategy to reverse mild NAFLD in overweight individuals. Analysis of colonoscopic bile aspirate samples revealed the impact of excess of free fatty acids on microbiome changes in a small intestine which affected microbiota composition down in the colon. Fatty acids which were not absorbed efficiently in the ileum of obese patients remained longer in the gut and might increase activity of microbes able to metabolise long chain fatty acids together with expression of other functions like bile acid transformation, BCAA metabolism sugars. Administration of xylitol reduced Streptococcus and supported A. hadrus growth which utilized lactate, acetate and produced butyrate.