Polycomb- and Methylation-Independent Roles of EZH2 as a Transcription Activator [microarray]. Polycomb- and Methylation-Independent Roles of EZH2 as a Transcription Activator [microarray]

EZH2 induces active transcription of the AR gene, thereby increasing AR level and promoting AR signaling. Importantly, EZH2-mediated activation of AR requires EZH2 protein occupancy at the AR gene promoter, but is independent of PRC2 as well as its histone methyltransferase activity Overall design: LNCaP/C4-2B cells were treated with DMSO or EPZ6438 (1uM) for 3 days. LNCaP/C4-2B cells were transfected with sicontrol or siEZH2 (CDS) for 3 days