MXtrodes: MXene-infused bioelectronic interfaces

Soft bioelectronic interfaces for mapping and modulating
excitable networks at high resolution and at large scale can enable
paradigm-shifting diagnostics, monitoring, and treatment strategies. Yet,
current technologies largely rely on materials and fabrication schemes that are
expensive, do not scale, and critically limit the maximum attainable resolution
and coverage. Solution processing is a cost-effective manufacturing
alternative, but biocompatible conductive inks matching the performance of
conventional metals are lacking. Here, we introduce MXtrodes, a novel class of
soft, high-resolution, large-scale bioelectronic interfaces enabled by Ti3C2­
MXene and scalable solution processing. We show that the electrochemical
properties of MXtrodes exceed those of conventional materials, and do not
require conductive gels when used in epidermal electronics. Furthermore, we
validate MXtrodes in a number of applications ranging from mapping large scale
neuromuscular networks in humans to delivering cortical microstimulation in
small animal models. Finally, we demonstrate that MXtrodes are compatible with
standard clinical neuroimaging modalities.

This repository contains the files necessary to reproduce the analysis for this manuscript:
(https://doi.org/10.1101/2021.03.01.433237)