Crystal structure of the inactive BRAF/MEK1 complex bound to IK-595
收藏Protein Data Bank Japan2026-02-11 更新2026-04-19 收录
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Crystal structure of the inactive BRAF/MEK1 complex bound to IK-595 Descriptor: 4-[2-chloro-3-(methylsulfamamido)phenoxy]-N-cyclopropyl-2-(2-fluoro-4-iodoanilino)-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxamide, Dual specificity mitogen-activated protein kinase kinase 1, MAGNESIUM ION, ... Authors: Yang, A. Deposit date: 2024-11-15 Release date: 2026-01-14 Last modified: 2026-02-11 Method: X-RAY DIFFRACTION (3.46 Å) Cite: The MEK-RAF molecular glue IK-595 has potent antitumor activity across RAS/MAPK pathway-altered cancers. Nat Cancer, 7, 2026
创建时间：
2024-11-15
