Human Cancer Models Initiative (HCMI) Cancer Model Development Center

The Human Cancer Models Initiative (HCMI) is an international consortium that is generating novel, next-generation, tumor-derived culture models annotated with genomic and clinical data. HCMI-developed models and related data are available as a community resource. The NCI is contributing to the initiative by supporting four Cancer Model Development Centers (CMDCs). CMDCs are tasked with producing next-generation cancer models from clinical samples. The cancer models include tumor types that are rare, originate from patients from underrepresented populations, lack precision therapy, or lack cancer model tools. Throughout the development process, the CMDCs utilize stringent internal QC measures to ensure both clinical and molecular integrity. These models are then annotated with clinical and genomic data and are available as a community resource.

人类癌症模型倡议（HCMI）是一个国际性联盟，致力于创建新颖的、下一代肿瘤来源的培养模型，这些模型经过基因组学和临床数据的注释。HCMI开发的模型及相关数据作为社区资源提供。美国国家癌症研究所（NCI）通过支持四个癌症模型发展中心（CMDC）参与该倡议。这些中心负责从临床样本中生产下一代癌症模型。这些癌症模型包括罕见肿瘤类型、源自代表性不足人群的患者的肿瘤、缺乏精准治疗或缺乏癌症模型工具的肿瘤。在整个开发过程中，CMDCs采用严格的内部质量控制措施，以确保临床和分子完整性。这些模型随后被添加临床和基因组数据注释，并作为社区资源提供。