Pan-reactome analysis of Streptomyces strains reveals association and disconnection between primary and secondary metabolism

Table S1.xlsx:

Details on genome data, biosynthetic gene cluster (BGC) statistics, and fastANI results for average nucleotide identity (ANI) among the 242 Streptomyces strains considered in this study.

Table S2.xlsx:

Details on all BGCs from antiSMASH among the 242 Streptomyces strains considered in this study and their corresponding gene cluster families (GCFs) from BiG-SCAPE.

Table S3.xlsx:

Validation results of genome-scale metabolic models (GEMs) for Streptomyces avermitilis MA-4680 and Streptomyces coelicolor A3(2) using phenotype microarray data, and for 20 Streptomyces strains using literature.

Table S4.xlsx:

Number of reactions, metabolites, and genes in the GEMs of the 242 Streptomyces strains.

Table S5.xlsx:

Jaccard similarities between presence vectors of reactions from the 242 Streptomyces GEMs and those of GCFs from BiG-SCAPE for the 242 Streptomyces strains.

Table S6.xlsx:

Summary of precursor requirements for all BGCs and the precursor biosynthetic capability of Streptomyces strains. A total of four categories were considered between the precursor producibility and precursor requirement.

Table S7.xlsx:

Metabolites and reactions suggested to be necessary for the biosynthesis of 20 secondary metabolite precursors according to the literature.

Table S8.xlsx:

List of genes predicted to be horizontally transferred among those within BGCs.

models_final_241108.zip:

SBML files of Streptomyces GEMs