Aortic gene expression profiles of double ApoE and ApoA-I knockout mice

Eight weeks old double apolipoprotein E and apolipoprotein A-I knockout mice (DKO) were fed either normal laboratory diet (chow) or high-fat (Western) diet for 6 or 22 weeks. High-throughput sequencing technologies were used to analyse the transcriptome of the aorta of apolipoprotein E knockout (EKO, GSE163657) and DKO mice to showcase the use of the software reString (https://github.com/Stemanz/restring), a functional enrichment results aggregator. Overall design: RNA-seq performed in mouse whole aortas from double apolipoprotein E and apolipoprotein A-I knockout mice (DKO), n=3-4 per experimental group, using the Illumina Genome Analyzer IIx. Two diets (chow, Western), two time points (6 weeks, 22 weeks).