Integrative ATAC-seq and RNA-seq Analyses of IPEC-J2 Cells Reveals Porcine Transcription and Chromatin Accessibility Changes Associated with Escherichia coli F18ac Inhibited by Lactobacillus reuteri

Escherichia coli (E. coli) is the main cause of postweaning diarrhea in pigs, leading to economic loss. As a probiotic, Lactobacillus reuteri (L. reuteri) has been used to inhibit E. coli in clinical applications; however, its integrative interactions with hosts remain unclear, especially in pigs. Here, we found that L. reuteri effectively inhibited E. coli F18ac adhering to porcine IPEC-J2 cells, and explored the genome-wide transcription and chromatin accessibility landscapes of IPEC-J2 cells by RNA-seq and ATAC-seq.