IPD-NHKIR - Non-Human Killer-cell Immunoglobulin-like Receptors

The IPD-NHKIR database provides a centralised repository for non-human KIR (NHKIR) sequences. Killer-cell Immunoglobulin-like Receptors (KIR) have been shown to be highly polymorphic at the allelic and haplotypic level. KIRs are members of the immunoglobulin superfamily (IgSF) formerly called Killer-cell Inhibitory Receptors. They are composed of two or three Ig-domains, a transmembrane region and cytoplasmic tail which can in turn be short (activatory) or long (inhibitory). The Leukocyte Receptor Complex (LRC) which encodes KIR genes has been shown to be polymorphic, polygenic and complex like the MHC.IPD-NHKIR 数据库为非人KIR（NHKIR）序列提供了集中化存储库。杀伤细胞免疫球蛋白样受体（Killer-cell Immunoglobulin-like Receptors，KIR）在等位基因与单倍型层面呈现高度多态性。KIR属于免疫球蛋白超家族（immunoglobulin superfamily，IgSF），曾被称为杀伤细胞抑制性受体。KIR由2至3个免疫球蛋白结构域、一个跨膜区域以及胞质尾区构成，其中胞质尾区可分为短尾（激活性）与长尾（抑制性）两种类型。编码KIR基因的白细胞受体复合体（Leukocyte Receptor Complex，LRC）已被证实具有多态性、多基因性且结构复杂，与主要组织相容性复合体（MHC）类似。

搜集汇总

背景与挑战

背景概述

IPD-NHKIR数据库是一个集中存储非人类杀伤细胞免疫球蛋白样受体序列的仓库。该数据库收录的KIR序列在等位基因和单倍型层面具有高度多态性，其基因编码区域类似于MHC，表现出多态性、多基因性和复杂性。