Slc11a2

ENCODES a protein that exhibits cadmium ion binding; cadmium ion transmembrane transporter activity; cobalt ion binding; INVOLVED IN cellular response to hypoxia; cellular response to iron ion; cellular response to tumor necrosis factor; PARTICIPATES IN hypoxia inducible factor pathway; iron uptake pathway; ASSOCIATED WITH abnormal iron homeostasis; ASSOCIATED WITH brain ischemia; duodenal ulcer; hypochromic anemia; FOUND IN apical part of cell; late endosome membrane; lysosomal membrane; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3H-1,2-dithiole-3-thione; 6-propyl-2-thiouracil

编码一种表现出镉离子结合、镉离子跨膜转运活性、钴离子结合的蛋白质；参与细胞对缺氧的响应、细胞对铁离子的响应、细胞对肿瘤坏死因子的响应；参与缺氧诱导因子途径、铁摄取途径；与异常铁稳态相关；与脑缺血、十二指肠溃疡、低色素性贫血相关；存在于细胞顶端部分、晚期内质网膜、溶酶体膜；与2,3,7,8-四氯二苯并-对二恶英、3H-1,2-二噻吩-3-硫酮、6-丙基-2-硫尿嘧啶相互作用。