Physicochemical data supporting the study of lipooligourea–lipid membrane interactions

This dataset supports the publication Mechanistic Insights into Lipooligourea–Lipid Membrane Interactions (Burdach et al., J. Phys. Chem. B, 2025), which investigates the membrane-disruptive properties of the synthetic cationic foldamer C10-OU4. The data includes Langmuir monolayer isotherms, QCM-D frequency and dissipation shifts, ATR-FTIR spectra (both p- and s-polarized), and calculations of chain order parameters and molecular tilt angles for model lipid systems mimicking Gram-positive bacterial membranes. The provided data illustrate the concentration-dependent mechanism of membrane disruption, from surface binding to full bilayer disintegration. This dataset enables further analysis and validation of the foldamer’s interaction with lipid bilayers and can support ongoing efforts in the design of membrane-active antimicrobial agents.