Transcription Factors Dlx1/2 Are Required for Making All Interneurons in the Olfactory Bulb [Pax6]

Purpose: To assess changes in gene expression profiles from the E16.5 wild type littermate controls cortex and Pax6 sey/sey mutant mice cortex. Methods: Total RNA was isolated and sequenced using an Illumina Hi-seq 2500. Raw data was analyzed using TopHat. Genes were considered significantly changed which perform P value <= 0.05. Results: Compared to controls, 173 genes were significantly down regulated, and 245 genes were up regulated in the RNA expression level of the mutant cortex. Overall design: Cortex RNA profiles of E16.5 Wild type mouse brain and Pax6 sey/sey mutant mice brain.