Gene expression signatures for GP73-induced non-obese nonalcoholic fatty liver disease

In searching for common and specific features of transcriptional changes associated with non-obese NAFLD induced by GP73 and obese NAFLD induced by high-fat diet (HFD), we used Agilent SurePrint G3 Mouse Gene Expression Microarray 8x60K to analyze gene expression in the livers isolated from mice 12 months after AAV-V or AAV-GP73 injection and in the livers isolated from AAV-V control mice fed a HFD for 12 months. Mice were injected with AAV-V and AAV-GP73 viruses intravenally, given a normal diet and a high-fat diet, and their liver gene expression was measured.