Quinolone Anticancer Database

Quinolone drugs, mainly acting on Gram-negative bacteria, are a very common class of antibiotics, which is a kind of antibacterial agent with selective inhibition of bacterial DNA helicase. Cancer remains one of the leading causes of human death and a major public health problem worldwide. However, there is still a lack of effective cancer treatment methods, existing cancer treatment methods not only can not be effective treatment, and may even bring huge side effects. It has been found that quinolone structure is an important structural feature in many compounds with good anticancer activity, and it is a potential tyrosine kinase inhibitor and anti-tumor topoisomerase Ⅰ inhibitor. Hybridization of quinolones with other anticancer pharmacophore may provide more effective anticancer drug candidates, some of which are already approved for cancer treatment or are in clinical trials. This database integrates the reported quinolones and constructs a knowledge base of quinolones to aid the treatment of cancer. A total of 436 compounds were included in the database, including compound names, structures, basic physicochemical properties, target sites, active cells, and cytotoxic data IC50, as well as corresponding references and links, in order to provide reference and research basis for the development of quinolones anticancer drugs and reduce research costs.