Erratum: <b><i>THADA</i></b> Gene Polymorphism and Prostate Cancer Risk: A Meta-Analysis

<b><i>Background: </i></b>The single nucleotide polymorphism (SNP) rs1465618 in <i>THADA</i> at 2p21 has been identified as being associated with prostate cancer (PCa) risk in Europeans; however, it is not clear whether the SNP is related to PCa risk in multiple populations. We investigated the association of rs1465618 in <i>THADA</i> with PCa in a Chinese population and carried out a meta-analysis in multiple populations, testing the relevance of this SNP for PCa risk. <b><i>Patients and Methods: </i></b>We genotyped the SNP using high resolution melting (HRM) analysis and assessed its association with PCa risk in a case-control study of 289 PCa patients and 288 controls in a Chinese population. A meta-analysis was carried out with 36,313 PCa patients and 36,485 controls to evaluate the association of rs1465618 with PCa risk in multiple populations. <b><i>Results: </i></b>rs1465618 in <i>THADA</i> was significantly associated with PCa risk (p = 0.026; odds ratio (OR) 1.327, 95% confidence interval (CI) 1.035-1.700). Furthermore, the rs1465618 variant genotype was associated with PCa aggressiveness (p = 0.044; OR = 2.053, 95% CI = 1.015-6.602) in the Chinese population. The meta-analysis showed that rs1465618 was significantly associated with PCa risk in multiple populations (p = 1.0×10^-8; OR = 1.127, 95% CI = 1.085-1.171). <b><i>Conclusion: </i></b>Our results showed that rs1465618 in <i>THADA</i> may be a shared susceptibility variant for PCa in multiple populations. <i>THADA</i> gene polymorphisms may impact PCa susceptibility and progression.

**背景：** 定位于2p21区域的THADA基因单核苷酸多态性（single nucleotide polymorphism, SNP）rs1465618，此前已被证实与欧洲人群的前列腺癌（prostate cancer, PCa）风险相关，但该SNP在多个人群中是否与前列腺癌风险存在关联仍不明确。本研究在中国人群中探究了THADA基因rs1465618与前列腺癌的关联，并开展多人群荟萃分析，以验证该SNP与前列腺癌风险的相关性。
**患者与方法：** 本研究在中国人群的病例对照研究中，纳入289例前列腺癌患者与288例健康对照，采用高分辨率熔解曲线（high resolution melting, HRM）分析法对该SNP进行基因分型，评估其与前列腺癌风险的关联；同时整合36313例前列腺癌患者与36485例对照数据开展荟萃分析，以评估多个人群中rs1465618与前列腺癌风险的相关性。
**结果：** 在中国人群中，THADA基因rs1465618与前列腺癌风险显著相关（p=0.026；比值比（odds ratio, OR）=1.327，95%置信区间（confidence interval, CI）：1.035~1.700）。此外，rs1465618变异基因型与中国人群的前列腺癌侵袭性显著相关（p=0.044；OR=2.053，95%CI：1.015~6.602）。荟萃分析结果显示，rs1465618在多个人群中均与前列腺癌风险显著相关（p=1.0×10⁻⁸；OR=1.127，95%CI：1.085~1.171）。
**结论：** 本研究结果表明，THADA基因rs1465618可能是多个人群中共有的前列腺癌易感变异位点。THADA基因多态性可能影响前列腺癌的易感性与疾病进展。

搜集汇总

背景与挑战

背景概述

该数据集是一个关于THADA基因多态性与前列腺癌风险关联的荟萃分析的更正文件。研究通过在中国人群中进行病例对照分析，并结合多人群荟萃分析，发现rs1465618 SNP与前列腺癌风险显著相关，并可能影响疾病进展。数据集属于医学领域，发布于2017年，采用CC BY 4.0许可证共享。