Microbes associate with host innate immune response in idiopathic pulmonary fibrosis. Homo sapiens

The goal of this study is to explore molecular mechanisms underpinning the progression-associated host-microbial interactions in IPF. Multi-omics analysis revealed that the majority (8/11) of the progression-associated pathways were involved in inflammatory response and pattern recognition receptors (PRRs), including NOD-, TOLL- and RIG-I-like receptor pathways. Microbial community richness was correlated with all of the three PRRs (Pearson's p 2 fold change in alpha smooth muscle actin expression (i.e. treated vs. untreated) was deemed CpG-ODN “responsive”. Therefore, 27/68 patients have CpG-ODN reponsive data. This series contains the gene expression data for the 68 PBMC samples from COMET-IPF participants.