Myosteatosis is associated with reduced survival and sexually dimorphic skeletal muscle transcriptional signatures in patients with pancreatic adenocarcinoma undergoing curative intent resection

Cachexia is highly prevalent in pancreatic adenocarcinoma (PDAC) with deleterious effects. Imaging-assessed surrogates of cachexia, such as sarcopenia, have been associated with poor outcomes, however, the importance of myosteatosis and the regulatory mechanisms underlying sarcopenia and myosteatosis remain poorly characterized.