Phage-resistant Hypervirulent Klebsiella pneumoniae strain

Hypervirulent Klebsiella pneumoniae (HvKP) is common in community acquired Klebsiella pneumoniae infection. In recent years, it is seriously threatening people's health because of its general susceptibility and multi site infection. The discover of Carbapenem-Resistant Klebsiella pneumoniae makes clinical anti-infective therapy a great challenge. Researchers have been attempted to utilize the phage to combat the crisis but have found that host bacteria are prone to developing phage resistance in a short period of time, preventing phage therapy from becoming a stable and long-lasting antimicrobial tool. In this study,we isolated a phage resistant HvKP strain and explore the possible reasons for the virulence decline of phage resistant strains by analyzing the expression of virous virulence factors to provide support for the prediction of phage resistance and to bring out a basis for decision-making on the long-term application of phage therapy.