Supplementary Material for: Initiation and Cessation Timing of Renal Replacement Therapy in Patients with Type 1 Cardiorenal Syndrome: An Observational Study

Background/Aims: Renal replacement therapy (RRT) is a
rescue therapy for patients with type 1 cardiorenal syndrome (CRS) with
poor prognoses. However, the optimal timing for initiation and cessation
of RRT remains controversial. The purpose of this study was to
determine the optimal timing of initiation and cessation of RRT for
patients with type 1 CRS. Methods: In this retrospective
analysis, patients with refractory type 1 CRS receiving RRT were divided
into 3 groups according to weaning from RRT and death within 90 days.
Baseline characteristics, underlying heart disease, comorbidities, drug
use before RRT, indicators of RRT initiation, and prognosis were
compared between the 3 groups. Results: Fifty-two patients
were enrolled, which included 27 males and 25 females with a mean age
of 70.7 ± 16.1 years and a 90-day mortality rate of 65.4%. The mean
urine output before RRT initiation was 800 mL/ 24 h in the
RRT-independent group, 650 mL/24 h in the RRT-dependent group, and 345
mL/ 24 h in the death group (p = 0.021). Additionally, there were
obvious differences in fluid balance between the 3 groups (167, 250,
and 1,270 mL, respectively, p = 0.016). Patients could be
successfully weaned from RRT when urine output was >880 mL and fluid
balance volume was <150 mL. Conclusion: The mean fluid
balance of survivors was remarkably less than that of the death group at
RRT initiation. RRT termination can be considered when urine output is
>880 mL/24 h and volume balance is <150 mL/24 h.