Loss of p21 expression enhances DNA damage, cholestasis and hepatocarcinogenesis in the liver
收藏Alliance of Genome Resources2026-08-01 收录
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Overexpression of p21 in NEMOdeltahepa animals protects against DNA damage, acceleration of hepatocarcinogenesis and cholestasis. As strengthened by our LPS stimulation experiments, we identified a novel protective role of p21 against DNA damage. Expression profiling of livers from wild type, NEMO, and NEMO-P21 null mice.
