Potential bulged G-quadruplex forming sequences (pG4-BS) in the human genome

Dataset containing the genomic coordinates of potential bulged G-quadruplex forming sequences (pG4-BS) in the human genome (Assembly: GRCh38). G-quadruplexes (G4s) are non-canonical DNA structures that are commonly found in single-stranded DNA (e.g., during transcription and replication). "Canonical" G4 finding algorithms have existed for a number of years and these utilize a generalized sequence model (G3+N1-7G3+N1-7G3+N1-7G3+; where "G3+" denotes a cluster of at least 3 continuous guanines and "N1-7" denotes any combination of one to seven nucleotides) to capture potential G4 forming DNA regions. Bulged G4s represent a novel subset of G4-like structures that incorporate non-guanine nucleotide(s) into one or more of their guanine clusters. Due to the highly diverse nature of the DNA sequence underlying these structures, no genome wide maps of pG4-BS are available for any organisms. Here, we provide a computationally derived dataset containing the genomic coordinates of pG4-BS in the human genome.