Fecal microbiota transplantation partly contributes to rescuing anxiety like behaviors in alcohol abuse mice

In this study, we used fecal microbiota transplantation (FMT) to investigate the effects of restoring normal gut microbiota in alcohol abuse mice (AL). AL mice exhibited reduced anxiety-like behavior without changes in locomotor activity. Based on 16S rRNA gene sequencing, we found a significant increase in microbial diversity in the recipient mice. Notably, the relative abundance of short-chain fatty acid (SCFA) producers such as Blautia, Pseudobutyrivibrio, Butyricimonas, and Lachnospiraceae significantly increased.