Ultrasound-Actived Piezo-Hot Carriers Trigger Tandem Catalysis Coordinating Cuproptosis-Like Bacterial Death Against Implant Infections

Implant-associated infections (IAI) remain challenging and life-threatening in medical healthcare due to bacterial biofilm formation on implant surface, highlighting the need for effective therapeutic methods. The proposed strategy holds great potential to confer implants with US-activated tandem catalysis to achieve anti-infection and osteogenic capacity simultaneously.