Supporting data for 'ANTI-CANCER POLYPHYLLIN D AND TIMOSAPONIN AIII: TARGET IDENTIFICATION, AND MECHANISM OF ACTION STUDIES"

Steroidal saponins are recognized for their diverse bioactivities, including anti-cancer, anti-inflammatory, antiviral, and immunomodulatory effects. Polyphyllin D (PD), a major bioactive steroidal saponin derived from the rhizome of Paris polyphylla, exhibits promising anti-cancer properties. Despite extensive investigations into its mechanisms, the direct target of PD remains unveiled. Timosaponin AIII (TAIII), a natural steroid saponin from Anemarrhena asphodeloides Bunge, has demonstrated significant anti-tumor and autophagy-inducing activities across various cancer types, yet its precise mechanism of action and direct target are not fully understood. In this research, the MOA and potential targets of PD and TAIII are explored.